Author Topic: Invention: Morphine-cannabis super-painkiller  (Read 12096 times)

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Offline Floyd01

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Invention: Morphine-cannabis super-painkiller
« on: August 13, 2008, 04:28:50 AM »
http://technology.newscientist.com/arti ... ef=dn14344
Morphine-cannabis super-painkiller

Pain can often be better managed when two types of painkiller are used together. For example, it has recently become known that cannabinoids such as THC, the psychoactive ingredient in cannabis, enhance the painkilling effects of opioids such as morphine.

Teaming them up could allow doses to become smaller, reducing the possibility of addiction. But a simple mixture of the drugs produces unpredictable results because the body absorbs them at different rates.

A possible solution is to join together THC and morphine to create a hybrid molecule that is snipped apart by the body, say Joseph Holtman and Peter Crooks at the University of Kentucky College of Medicine in Lexington, Kentucky.

Their idea is to bind the two drugs together using a linking molecule such as an ester. When the body snips this linking group, both drugs are released at the site where they are needed. That should ensure both drugs will be absorbed at the same rate, making it easier to work out doses for patients.

Read the full morphine-cannabis supermolecule painkiller patent application.
« Last Edit: December 31, 1969, 07:00:00 PM by Floyd01 »

Offline Anonymous

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« Reply #1 on: August 15, 2008, 02:41:45 PM »
Man fuck that!

That's gonna be more addictive than THC and Opiates combinded, DUH!!!!

...Mother Nature did a fine job... leave her alone!
« Last Edit: December 31, 1969, 07:00:00 PM by Anonymous »

Offline crazydewman

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« Reply #2 on: August 24, 2008, 09:56:04 PM »
THC is not physically addictive
psychological dependence is a whole other issue (which can lead to physical effects)
« Last Edit: December 31, 1969, 07:00:00 PM by crazydewman »

Offline Glandmaster

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« Reply #3 on: August 24, 2008, 11:48:51 PM »
Big pharma is always looking for ways to get around the USAs world policy on cannabis. Search for Marinol or Sativex...

I got the bulk of the Sativex patients after the first trial in the UK. It worked for a lot of them which should be encouraging except these MS sufferers were dumped at the end of the trial to go back on pharma meds that we know DONT work. All reported that the cannabis we supplied (raw, tincture, chocolate etc) was at least as good as sativex and lacked a lot of the side effects. Their own doctors were also impressed albeit informally...

Sativex, like Marinol does all it can to remove all the bonuses of taking cannabis - the high feeling, the speed of the effect, the ease of titrating a dose - after all what use would these be to someone in dire pain? Sativex is only of use to those with nueropathic pain - I imagine this new drug idea will have similar restrictions.

I get to try a lot of pharma drugs as I am disabled and I can say that Marinol was worse for me than morphine when it comes to the side effects. I could just about function on morphine - Marinol just wiped me out for hours at a time. Its also the case that I am allergic to many drugs due to my disability and opiods seem to be among the worst for me. So I wouldnt be able to take this drug anyway. Other people may have difficulty with THC - which is not the only active ingredient in cannabis of course. I prefer CBD for pain relief however people with HIV may disagree.

People often get excited that big pharma is working with cannabis however it really harms the pro medical argument. All I got from the Home Office while I was actively campaigning with the clinic was 'we are allowing trials for Sativex'.

The only way forward is to allow patients to work with their doctors and people like me to work out the best approach for them (which will change over time - the idea is you STOP coming to see me as you get the hang of things or get better!) and perhaps most importantly to develop a relationship with the plant they are using to regain some quality of life. I would argue that its the relationship thats the most important aspect for those with chronic conditions, as Bucky Fuller put it 'we live in a interregenerative universe' and while this fact doesnt change when you have a chronic condition it sure helps to have a solid reminder!
« Last Edit: December 31, 1969, 07:00:00 PM by Glandmaster »

Offline Glandmaster

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« Reply #4 on: August 28, 2008, 06:28:02 PM »
Here is a pharma idea that may actually have some merit:

http://http://arstechnica.com/journals/science.ars/2008/08/26/killing-bacteria-with-cannabis

(If you ignore the irony that I may be protected from cross infection using cannaboids whilst at hospital but I cannot use them to control my chronic conditions...)
« Last Edit: December 31, 1969, 07:00:00 PM by Glandmaster »

Offline xiaojerey

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Re: Invention: Morphine-cannabis super-painkiller
« Reply #5 on: June 27, 2012, 03:18:05 AM »
xiaojerey, we do not allow spam or commercial postings in here. You have been banned from posting.
« Last Edit: June 27, 2012, 05:24:31 PM by Stonehenge »

Offline Bushpig

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Re: Invention: Morphine-cannabis super-painkiller
« Reply #6 on: September 25, 2012, 08:20:21 AM »
Check here for an anti inflammatory and pain killer that affects the endo cannabinoid system, seems to have little side effects due to its existance in the body.  It has had a dramatic effect on my mother in laws arthritic condition.

http://en.wikipedia.org/wiki/Palmitoylethanolamide   (Normast)

Booooshpig

Offline dendro

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Re: Invention: Morphine-cannabis super-painkiller
« Reply #7 on: October 07, 2012, 03:41:59 AM »
Thanks, booosh, I'm going to have my son, who has fibromyalgia, seek after a prescription of this drug. Lyrica didn't help him very much. He's using a fair amount of weed now, likely just to hit his PEA receptors and get some pain relief. Normast likely will target these receptors without the THC high.

How come none of our doctors have told us about this compound? I want to try it for migraine and headache, as well as liver inflammation. Hey Doc!
earth peace through self peace...

Offline dendro

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Re: Invention: Morphine-cannabis super-painkiller
« Reply #8 on: October 10, 2012, 03:32:14 PM »
OK, so Normast is not available by prescription in the US, and thus is not covered by medical insurance.  At over $150 for the first month's supply, this is an expensive OTC item for Americans, and some of us are cash poor.

So I'll mention this to my doctor, but sadly I doubt she will be able to help us with Normast.
earth peace through self peace...

Offline Stonehenge

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Re: Invention: Morphine-cannabis super-painkiller
« Reply #9 on: October 11, 2012, 07:00:14 PM »
It seems to be available in europe, i saw an ad for it, they wanted about 26 euro for 20 pills. That does seem a little expensive even if you could get it in the states. They frown on importing unapproved medicines, it would have to be smuggled. But at least it exists.
Stoney

Re: Invention: Morphine-cannabis super-painkiller
« Reply #10 on: March 25, 2015, 06:59:32 PM »
Dendro, I knew a lady who's daughter was told she had 'fibromyalgia' for years until she was diagnosed with Lyme disease and is finally getting treatment.  Fibromyalgia is really just a description of symptoms with no attempt at identifying the cause so I don't know how helpful of a diagnosis it is.   You already know you're having muscle pain.  Lyme disease is tricky to diagnose and treat becease they burrow so deep into cells.  Science is advancing here though and it may be worth ruling out if you already have not.  Good luck either way. 
« Last Edit: March 25, 2015, 11:14:46 PM by chiefbtflapflaps »

Offline Stonehenge

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Re: Invention: Morphine-cannabis super-painkiller
« Reply #11 on: March 25, 2015, 08:18:27 PM »
Lyme is a terrible disease, they never really recover from it. The long term effects can be devastating. I used to think they just gave some antibiotics and it went away, but not so.
Stoney

Re: Invention: Morphine-cannabis super-painkiller
« Reply #12 on: March 25, 2015, 11:26:03 PM »
they're scary little buggers. 

Offline IOPan

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Re: Invention: Morphine-cannabis super-painkiller
« Reply #13 on: April 02, 2016, 07:45:49 PM »
fyi found some info on sugar to morphine biochemically via tweaked e.coli as a yeast culture
"When I was five years old I saw an insect that had been eaten by ants and of which nothing remained except the shell. Through the holes in its anatomy one could see the sky. Every time I wish to attain purity I look at the sky through flesh." Dali

Offline IOPan

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Re: Invention: Morphine-cannabis super-painkiller
« Reply #14 on: April 02, 2016, 07:55:06 PM »
oh btw lyrica imo is just another prodrug like gabapentin ie neurontin gross stuff primary for sezures. but does nothing for me. not even willing to try it gonna see a doc for bupenorphine or norco to get off tramadol which is garbage too at least for me, my liver dosen't seem to prosess it to it's more potent form. Also you might see what a compounding pharm could do and just change the ratio?
"When I was five years old I saw an insect that had been eaten by ants and of which nothing remained except the shell. Through the holes in its anatomy one could see the sky. Every time I wish to attain purity I look at the sky through flesh." Dali