i heard salvia divinorum's effects are increased by MAIO's but can they be decreased by some MAIO's like anti-depressants, adhd medication, and other maoi inhibitors or can salvinorin be blocked by a sertain drug or chemical? is that why some people cannot experience the effects quite like others?

You know in my experiance Salvia destroys all other drugs.

I've done it drunk, and BAMMMMM I didn't feel drunk anymore I just felt Salvinorin

I've done it on research chemicals and BAMMMMMMM it cut right through them

I've done it on Gabapentin/Neurontin and low and behold it made the effect explode away and I was thrown into a salvia state

I've done it on MJ and WHAAAAAAAAAAAAAAAAAAAABAMMMMMMMMMMM yup it exploded right through it leaving only flamming reminence of memories of even doing it.

I wouldn't worry so much about all this research my friend, if it isn't working for you that's where Salvia's wonderful reverse tollerance kicks in. The more you do it the more it will effect you, Salvia will treat you well in time.

I've met quite a few people who it didn't effect much when they first started, but by about 10 uses they were getting the same effects as me....which trust me are way powerful enough

I'm not sure if you are smoking the Salvia right so here is a brief tutorial.

1. YOU CAN'T BE A WUS!!!
2. Pack a HUGE bowl of crushed into a powder salvia leaves into the biggest water bong/pipe you can get near.
3. Torch the whole bowl taking a hit of legendary proportions (YOU CAN'T BE A PANSY ONCE MORE).
4. Hold the smoke in your lungs and as soon as you exhale without even taking any time at all go strait into your next hit (if you are passing Salvia you are doing it wrong 1Bowl=1person)
5. If you do this you will forget how to smoke after a few hits and have to stop, but on the bright side you've reached the effects you want.

what about a pipe?

You can use a pipe, just that the smoke can be a little harsh and the water helps to cool down the smoke. For Sally to work, she needs a lot more heat than just the other green friend or tobacco. Hyakitaki's directions are on the money and make sure that you are away from distractions, ie roomates and tv, and perhaps a sitter would be a good idea also. BTW When smoking, take as large of a hit and hold it for as long as possible before exhaling and then repeat until you can no longer smoke and you are visiting Sally's world.

Man, it's really WUSSY to smoke Salvia. Real psychonaughts snort huge quantities of fresh leaves, shredded finely and sprinkled with a little cyan pepper to increase absorption!

Pansies!

Does that actually work?

I heard recently that the whole thing about holding a toke forever is wrong.... Remember now, ya gotta get all that Salvinorin into your system in a finite time slot right?? I have been suggesting to newbies lately, that they get what hit they can hold, then hold it for 1/2 as long as they normally hold MJ, exhale, then repeat, until they forget what they are doing... Hasn't failed once ------------ sal

I have to agree from what i've seen YOU HAVE TO HOLD IT, but not for more than about 7 or so seconds.

one must look to other kappa opioid agonists as a possible model to what maois and agonists would do. maybe increase the possibility of amnesia, or i think it would make the uncomfortable effects stronger, if anything. ( heating, sweating ). or perhaps it would allow oral administration ? there were 3 new diterpenoids recently discovered that also act as kappa opioid agonists.

From what I can tell things like Harmala alkaloids synergize with Salvinorin A, and they do not seem to actually inhibit the metabolizing of it per se. Whatever the case the SD trip wil, also, seem to last longer.
Thus, a good mix it was. However, it is not like mixing DMT with Harmala alkaloids, or another MAOI.

Yes, one usually holds it for 10 seconds. 20 to 30 seconds is just overkill.